More information in the GO evidence code guide
,UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Complex I functions in the transfer of electrons from NADH to the respiratory chain. In Escherichia coli the expression of the nuo genes encoding the proton pumping NADH dehydrogenase I is stimulated by the presence of fumarate during anaerobic respiration. NADH dehydrogenase (ubiquinone) Narrower (2) NADH dehydrogenase complex (plastoquinone) respiratory chain complex I location. lhe pH optimum for the enzyme was 7.0. lhe adivity was found to be severely inhibited by p … The electrons are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH2). in UniProtKB/Swiss-Prot.
,Manually curated information for which there is published experimental evidence.
Related topics 3 relations. Manual assertion based on opinion ini, DNA Data Bank of Japan; a nucleotide sequence database, Ensembl eukaryotic genome annotation project, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Antibodypedia a portal for validated antibodies, GeneCards: human genes, protein and diseases, BioGRID ORCS database of CRISPR phenotype screens, ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data, The Gene Wiki collection of pages on human genes and proteins, Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens, The Stanford Online Universal Resource for Clones and ESTs, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations. J. Med. Because chloroplast NDH is structurally related to mitochondrial NADH dehydrogenase (Matsubayashi et al., 1987), and electron transport is linked to the plastid terminal oxidase (Okegawa et al., 2010), NDH‐mediated electron transport is often called chlororespiration; this name is especially appropriate when this electron transport occurs in the dark (Peltier and Cournac, 2002). NADH-derived electrons can enter its mitochondrial respiratory chain either via a proton-translocating complex I NADH-dehydrogenase or via three putative alternative NADH dehydrogenases. The current subsections and their content are listed below:,This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
,This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.
,This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting).
This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s).
It should be noted that while, in theory, two different sequences could Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.
,This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Protein sets from fully sequenced genomes. SWISS-MODEL Repository - a database of annotated 3D protein structure models, Database of comparative protein structure models, Protein Data Bank in Europe - Knowledge Base, evolutionary genealogy of genes: Non-supervised Orthologous Groups, The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms, Identification of Orthologs from Complete Genome Data, Database for complete collections of gene phylogenies, Integrated resource of protein families, domains and functional sites. The P. aeruginosa genome encodes at least three bioinformatically predicted NADH dehydrogenases (NADH:quinone oxidoreductases). 612638 - NADH DEHYDROGENASE 1 ALPHA SUBCOMPLEX, 11; NDUFA11 - NDUFA11 In affected offspring from 3 consanguineous families of Israeli Bedouin origin with severe mitochondrial complex I deficiency nuclear type 14 (MC1DN14; 618236), Berger et al. It also includes information pertinent to the sequence(s), including length and molecular weight. A 167A:2114-2121(2015), Human polymorphisms and disease mutations, Human entries with polymorphisms or disease mutations. While many of its clinical applicati … Synonym: Complex 1, mitochondrial respiratory chain, 49-KD subunit, NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase), NADH dehydrogenase (ubiquinone) Fe-S protein 2, NADH-ubiquinone oxidoreductase NDUFS2 subunit 2018. Sequence conflicts are usually of unknown origin.
. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. Bgee dataBase for Gene Expression Evolution, Genevisible search portal to normalized and curated expression data from Genevestigator. We'd like to inform you that we have updated our Privacy Notice to comply The algorithm is described in the ISO 3309 standard.What is the canonical sequence?
canonicali sequence. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.
,This subsection of the 'Interaction' section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the 'Function' section).
,This subsection of the 'Interaction' section provides information about binary protein-protein interactions. The flow of electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix.
Manually curated information that is based on statements in scientific articles for which there is no experimental support.
This is known as the 'taxonomic identifier' or 'taxid'.,This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. submitochondrial location of the 32-kD NADH dehydrogenase. Complex I functions in the transfer of electrons from NADH to the respiratory chain. There are a number of rotenone-insensitive NADH dehydrogenases located on the outer and inner surface of the inner mitochondrial membrane in plant and yeast mitochondria. It is useful for tracking sequence updates.
[10] Initially, NADH binds to Complex I and transfers two electrons to the isoalloxazine ring of the flavin mononucleotide (FMN) prosthetic arm to form FMNH2. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue, ferricyanide or P-nitroblue tetrazolium. MT-ND5 is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 5 protein (ND5).However UniProtKB may contain entries with identical sequences in case The ND5 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. NADH dehydrogenase (ubiquinone) Complex I ( EC 1.6.5.3 ) (also referred to as NADH:ubiquinone oxidoreductase or, especially in the context of the human protein, NADH dehydrogenase (ubiquinone) ) is an enzyme of the respiratory chains of myriad organisms from bacteria to humans. In biochemical terms, lactate is a dead end in metabolism.
This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.
Sequence processingi: The displayed sequence is further processed into a mature form. MT-ND5 is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 5 protein (ND5). Cardiac and renal involvement as well as symptoms such as myopathy and lactic acidosis can also be observed.Inferred from Direct Assay
,The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
,Inferred from Mutant Phenotype
[4] The ND5 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. The NDUFA1 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. The NADH dehydrogenase activities of membranes (0.4 to 0.5 μmol min −1 mg −1) did not differ significantly in the mutant and the wild-type strains, suggesting that the lack of a functional Na +-NQR complex in the mutant was compensated for by a nonelectrogenic NADH dehydrogenase encoded on the genome of V. cholerae. [5], The MT-ND5 product is a subunit of the respiratory chain Complex I that is supposed to belong to the minimal assembly of core proteins required to catalyze NADH dehydrogenation and electron transfer to ubiquinone (coenzyme Q10). The NADH then transfers the electrons to FMN present in the intermembrane space via the complex I (NADH dehydrogenase). is extremely low. These are stable identifiers and should be used to cite UniProtKB entries. Phosphorylation of PDH is mediated by a special regulatory enzyme, pyruvate dehydrogenase kinase. External NADH dehydrogenase. Genet. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.,This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.
,This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.
,This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e. This section is only present in reviewed entries, i.e. J Biol Chem. NADH DEHYDROGENASES - NADH dehydrogenases, are part of the mitochondrial respiratory chain, which catalyzes transfer of electrons from NADH to ubiquinone. This pathway is found in many mircoorganisms and is also present in the cells of higher organisms when the availability of oxygen in muscle tissue is low. Found in a patient with histiocytoid cardiomyopathy; unknown pathological significance. NADH Dehydrogenase (Ubiquinone) Complex I is the first enzyme complex in the respiratory chain, and it accepts electrons from NADH+H+ derived from fat, carbohydrate, and amino acids to create an electrochemical gradient across the inner mitochondrial membrane. The information is extracted from the scientific literature and diseases that are also described in the OMIM database are represented with a controlled vocabulary in the following way:
,This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.
,This section describes post-translational modifications (PTMs) and/or processing events.
,This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.
,This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.
, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial,This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.
,This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. This NADH dehydrogenase is located at the inner surface of the cytoplasmic membrane (like succinic dehydro- genase and ATPase) as was shown with immunoabsorption experiments. Variations in human MT-ND5 are associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) as well as some symptoms of Leigh's syndrome and Leber's hereditary opti… Membrane vesicles oxidize NADH, presented at the outer surface, at a high rate. MITOCHONDRIAL COMPLEX I - ACCESSORY SUBUNITS -
Manually curated information for which there is published experimental evidence.
Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.,This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. The regulatory sites required for the induction by fumarate, nitrate and O 2 are located at positions around –309, –277, and downstream of –231 bp, respectively, relative to the transcriptional‐start site. Both insertions were mapped to min 51, and sequence analysis revealed that both mutated genes encode proteins homologous to subunits of mitochondrial NADH dehydrogenase I. Antiaris africanais a plant in Nigeria, generally used for the treatment of nervous disorders. Pyruvate dehydrogenase may be allosterically activated by fructose-1,6-bisphosphate and is inhibited by NADH and acetyl-CoA. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.
,This subsection of the 'Entry information' section provides one or more accession number(s). [6][7][12][13], MT-ND5 interacts with Glutamine synthetase (GLUL), LIG4 and YME1L1.[4]. We have already reported the neuroprotective effect of crude extract of A. africana The inner membranes of mitochondria contain three multi-subunit enzyme complexes that act successively to transfer electrons from NADH to oxygen, which is reduced to water (Fig. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication GO - Biological process i All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. The respiratory chain is located in the cytoplasmic membrane of bacteria but in case of eukaryotic cells it is located on the membrane of mitochondria. ... Related topics.
An evidence describes the source of an annotation, e.g. The MT-ND4 gene provides instructions for making a protein called NADH dehydrogenase 4. [6][7], MT-ND5 is located in mitochondrial DNA from base pair 12,337 to 14,148. The chemical reaction these enzymes catalyze are generally represented with the follow equation; The version number for both the entry and the canonical sequence are also displayed.
,This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
,This section contains any relevant information that doesn't fit in any other defined sections
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, mitochondrial respiratory chain complex I, Linear skin defects with multiple congenital anomalies 3 (LSDMCA3), Mitochondrial complex I deficiency, nuclear type 30 (MC1DN30), Am. ' section describes the sequence of naturally occurring alternative protein isoform ( )... Necessary for FAD binding dehydrogenase 4 a special regulatory enzyme, pyruvate kinase. Enzyme is the most important clinically of several dehydrogenases occurring in human serum the versions... In Nigeria, generally used for the treatment of nervous disorders NADH quinone. Attempt to define more clearly the role of the mitochondrial respiratory chain from: mitochondrial studies. Dna from base pair 12,337 to 14,148, at a high rate are... 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