(viii) During the periods of physiological stress. -, Balasubramaniam S, Christodoulou J, Rahman S. Disorders of riboflavin metabolism. 24. riboflavin deficiency that can affect our body’s metabolism . Riboflavin deficiency has been studied in many animal species and always results in failure to grow. Dietary insufficiency can cause angular cheilitis (cracks at the corners of the mouth), anemia, burning mouth, sore throat, and cataracts. Riboflavin deficiency usually occurs with deficiencies of other B vitamins due to a diet low in vitamins or an absorption disorder. What are the problems caused by deficiency of protein. 0 % 0 % Evidence. In: StatPearls [Internet]. Genes provide instructions for creating proteins that play a critical role in many functions of the body. Disclaimer Some preventable diseases manageable with adequate riboflavin are anemia, cataracts, migraines, and thyroid dysfunction. Riboflavin supplement during pregnancy and after birth reduced neonatal death and metabolic disorders. -, O'Callaghan B, Bosch AM, Houlden H. An update on the genetics, clinical presentation, and pathomechanisms of human riboflavin transporter deficiency. And even a mild case of riboflavin deficiency can lead to anemia, which can cause … And even a mild case of riboflavin deficiency can lead to anemia, which can cause … Riboflavin is a key vitamin for your health and has an impact on nearly every system in the body. Symptoms and signs include sore throat, lesions of the lips and mucosa of the mouth, glossitis, conjunctivitis, seborrheic dermatitis, and normochromic-normocytic anemia. A deficiency of Vitamin B2 in the body can be primarily due to poor vitamin sources in one's daily diet or as a result of conditions that affect its absorption in the intestine. Save Recommend Share . Vitamin B2 (Riboflavin) deficiency symptoms include anemia (interfere iron absorption), blurred vision, itching in eyes, watery eyes, eye fatigue, eye’s increased sensitivity toward light, cataract, dermatitis, migraine, night blindness, cracked corners of the … Description Riboflavin, also called vitamin B2, is a water-soluble vitamin. Severe, long-term riboflavin deficiency causes a shortage of red blood cells (anemia), which makes you feel weak and tired. Ariboflavinosis is a condition resulting from deficiency of riboflavin or Vitamin B2. Riboflavin deficiency can cause ariboflavinosis, which may result in cheilosis (cracks in the lips), high sensitivity to sunlight, angular cheilitis, glossitis (inflammation of the tongue), seborrheic dermatitis or pseudo-syphilis (particularly affecting the scrotum or labia majora and the mouth), pharyngitis (sore throat), hyperemia, and edema of the pharyngeal and oral mucosa. No developmental disorders could be demonstrated in newborns whose mothers had clinical or laboratory signs of riboflavin deficiency (Heller 1974).In the same study, vitamin B 2 concentrations in the cord blood were four times higher than in the maternal blood. When the condition begins in infancy, the first symptom often is breathing problems, which can be life-threatening. Cirrhosis of the liver is often accompanied by signs of inadequate supply of riboflavin, presumably due to improper utilisation of the vitamin. Riboflavin transporter deficiency is caused by a variation in one of three genes – SLC52A1 gene (causing riboflavin transporter deficiency type 1), the SLC52A2 gene (riboflavin transporter deficiency type 2), and the SLC52A3 gene (riboflavin transporter deficiency type 3). Treasure Island (FL): StatPearls Publishing; 2020 Jan. Would you like email updates of new search results? For preventing and treating low levels of riboflavin (riboflavin deficiency): Riboflavin 2 mg once, then 0.5-1.5 mg daily for 14 days has been used. Hyperemia and edema around the throat, liver degeneration, and hair loss can also occur along with reproductive issues. PreserveArticles.com: Preserving Your Articles for Eternity, Short notes on the functions, sources and deficiency of Vitamin –K, Short Essay on the Deficiency of Vitamin D, Short notes on the functions, sources and deficiency of Riboflavin, 5 most important causes of Vitamin A Deficiency in our body, 9 important symptoms of vitamin A deficiency. Jun 25, Vitamin B2 (Riboflavin) Some preventable diseases manageable with adequate riboflavin are anemia, cataracts, migraines, and thyroid dysfunction. Expert Rev Neurother. With a healthy digestive system, the body can absorb most of the nutrients from the diet, so it is important to get most of the riboflavin from dietary sources. Pasteurisation, evaporation and drying of milk causes 10 to 20 per cent loss of riboflavin. Deficiency: Causes severe malnourishment; Presentation .  |  Food sources include eggs, green vegetables, milk and other dairy product, meat, mushrooms, and almonds. Short circuiting operations in the gastrointestinal tract, likewise lead to insufficient absorption. 2018 Dec;18(12):933-943. Additionally, anorexic individuals rarely consume adequate riboflavin, and lactose intolerant individuals may not consume milk or other dairy products which are good sources of riboflavin. Because riboflavin assists many enzymes with various daily functions throughout the body, a deficiency can lead to health problems. Its manifestations are glossitis, angular stomatitis, cheilosis, anemia, and peripheral neuropathy.… Riboflavin Deficiency (Riboflavin Deficiency Disease): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. A riboflavin deficiency is nutritional deficiency characterized by inadequate amounts of riboflavin, a B-vitamin that plays an important role in a number of physical and metabolic processes. Vitamin B2 will break down fats, as well as convert proteins into amino acids and carbs into glucose. Please enable it to take advantage of the complete set of features! Riboflavin deficiency usually occurs with other B vitamin deficiencies. The effect of estrogen, Poultry Science 40:1390.  |  Treatment consists of oral or, if needed, intramuscular riboflavin. The fact is that riboflavin is very important for your vision and here’s the proof: In one study, 47 patients who had light sensitivity, eyestrain, burning eyes, eyes that watered easily, and eye fatigue – many of the above riboflavin deficiency symptoms – were given riboflavin. 0. Riboflavin deficiency can lead to a whole host of health problems, from fatigue to cataracts. Riboflavin deficiency can cause fatigue, swollen throat, blurred vision, and depression. The coenzymes are flavin mono­nucleotide (FMN) and flavin adenine dinucleatide (FAD). Riboflavin deficiency can cause skin disorders, sores at the corners of your mouth, swollen and cracked lips, hair loss, sore throat, liver disorders, and problems with your reproductive and nervous systems. Riboflavin (vitamin B2) deficiency is caused by inadequate dietary intake, malabsorption, and impaired metabolism. It may be found in individuals who consume a marginal diet devoid of dairy products, other animal protein sources and leafy vegetables. Riboflavin deficiency can cause fatigue, swollen throat, blurred vision, and depression. Genes provide instructions for creating proteins that play a critical role in many functions of the body. Riboflavin, vitamin B2, is a water-soluble and heat-stable vitamin that the body uses to metabolize fats, protein, and carbohydrates into glucose for energy. All the articles you read in this site are contributed by users like you, with a single vision to liberate knowledge. The administration of some antibiotics results in an excessive output of riboflavin causing a deficiency. cheilosis (inflammation of lips, scaling and fissures at the corners of the mouth) corneal vascularization; Physiological characteristics associated with mutant gene in chicken that causes deficiency of riboflavin 4. Treatment with riboflavin therapy has been used since 2010 and appears to be effective and possibly life-saving. Riboflavin is also called vitamin B2. It is present in the body tissues as the coenzymes or flavoproteins. Riboflavin is lost in the process of heating e.g. We postulate that haploinsufficiency of this riboflavin transporter causes mild riboflavin deficiency, and when coupled with nutritional riboflavin deficiency in pregnancy [ncbi.nlm.nih.gov] Maternal riboflavin deficiency , resulting in transient neonatal-onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B. Riboflavin has a yellow-green fluorescent pigment, which causes urine to turn yellow, indicating the body is absorbing riboflavin. Riboflavin also helps convert tryptophan to niacin, which activates vitamin B6. The determination of vitamin B by means of its influence on … To research the causes of Riboflavin deficiency, consider researching the causes of these these diseases that may be similar, or associated with Riboflavin deficiency:  |  Diagnosis is usually clinical. Riboflavin AI =Adequate Intake mg =milligram (Illustration by GGS Information Services/Thomson Gale.) Besides anxiety, depression, and headaches, look out for cracked lips, mouth sores, and a red swollen tongue so you can correct your diet. 2013;19(14):2649-75. doi: 10.2174/1381612811319140014. Other articles where Vitamin B2 deficiency is discussed: childhood disease and disorder: Malnutrition: Riboflavin deficiency results in lesions of the skin and corners of the mouth, with a peculiar smoothing of the tongue. These effects occur with the help of two coenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). Severe, long-term riboflavin deficiency causes a shortage of red blood cells (anemia), which makes you feel weak and tired. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. J Nutr. Yes, Riboflavin deficiency causes complications if it is not treated. Types of Vitamin B. Vitamin B1 (Thiamine) Vitamin B2 (Riboflavin) Vitamin B3 (Niacin) Vitamin B5 (Pantothenic Acid) Vitamin B6 (Pyridoxine) Vitamin B7 (Biotin) Vitamin B9 (Folate) (More information) Riboflavin deficiency has been linked to preeclampsia in pregnant women. NIH Stores of riboflavin are guarded very carefully in the body, so that even during severe deficiency a little amount is found in the liver, kidney and heart. Beriberi is a consequence of thiamine deficiency. In the same way diarrheal disorders such as amoebic and bacillary dysentery, chronic ulcerative colitis (painful ulcers in the large intestines) interfere with absorption from the intestinal tract. What are the signs of riboflavin deficiency? Learn how riboflavin helps in fight against fatigue and how to identify whether or not you suffer from vitamin B2 deficiency. Inheritance is autosomal recessive. Riboflavin deficiency can lead to improper digestion of protein, fats, and carbs—the three major macronutrients that the body uses for fuel. In the intestine makes Vitamin B, less available in the body. Udhayabanu T, Manole A, Rajeshwari M, Varalakshmi P, Houlden H, Ashokkumar B. J Clin Med. When there is too little riboflavin in the food, it causes what people call a primary riboflavin deficiency. Symptoms of Riboflavin deficiency including 4 medical symptoms and signs of Riboflavin deficiency, alternative diagnoses, misdiagnosis, and correct diagnosis for Riboflavin deficiency signs or Riboflavin deficiency symptoms. The use of alkalies like soda also causes it to deteriorate. Some people who have something wrong with their guts get what people call a secondary riboflavin deficiency: even if there is plenty of riboflavin in the food, the sick gut cannot get it out of the food and pass it on to the blood. Privacy Policy The use of alkalies like … Without an adequate amount of riboflavin, macronutrients like carbohydrates, fats, and proteins cannot be digested and maintain the body. J Inherit Metab Dis. Affected individuals typically have hearing loss caused by nerve damage in the inner ear (sensorineural hearing loss) and signs of damage to other nerves.. -, Peechakara BV, Gupta M. StatPearls [Internet] StatPearls Publishing; Treasure Island (FL): 2020. Causes Alcoholics are at increased risk of vitamin B2 (riboflavin) deficiency due to decreased intake, decreased absorption, and impaired utilization of riboflavin. Causes and Risk Factors. PreserveArticles.com is an online article publishing site that helps you to submit your knowledge so that it may be preserved for eternity. Suspected outbreak of riboflavin deficiency among populations reliant on food assistance: a case study of drought-stricken Karamoja, Uganda, 2009-2010. 0. For preventing and treating low levels of riboflavin (riboflavin deficiency): Riboflavin 2 mg once, then 0.5-1.5 mg daily for 14 days has been used. Riboflavin transporter deficiency neuronopathy is a disorder that affects nerve cells (neurons). Copyright. Apr 12, Biochemistry, Water Soluble Vitamins . Google Scholar. 0. This fact might be anticipated in view of the importance of flavoprotein enzymes in cellular metabolism. Riboflavin becomes inactive or is destroyed in sunlight: A bottle of milk if kept out in direct sunlight for 3½ hours loses 75% of the riboflavin. 0. Riboflavin deficiency can affect multiple pathways in the metabolism of vitamin B 6, folate, niacin, and iron. COVID-19 is an emerging, rapidly evolving situation. A variety of factors may cause brittle hair and nails. It is absorbed from the upper part of the small intestine. 2011 Jan;32(1):E1976-84. Separation and determination of vitamin B6 group (pyridoxine, pyridoxal, pyridoxamine, pyridoxal-phosphate and pyridoxamine-phosphate); separation by paper electrophoresis of riboflavin (riboflavin, FMN and FAD) and of nicotinamide (nicotinamide, DPN and TPN) groups. 3 3. Deficiency disease of riboflavin Vitamin b2 deficiency diseases or Riboflavin deficiency include oral and facial lesions, sore throat, redness and swelling of mouth lining. 1954 Jun;14(2):212-8. doi: 10.1016/0006-3002(54)90160-2. Riboflavin deficiency can be associated with inadequate dietary intake, malabsorptive conditions, for example, celiac disease, but is often seen in combination with a generalized B vitamin deficiency. Take, for example, vitamin B12: don’t get enough of this vitamin, and your energy levels throughout the day might sag – with your mind constantly turning, perhaps, to thoughts of sleep in your warm cozy bed. The diagnosis is confirmed by measuring riboflavin excreted in urine or by giving riboflavin supplements, which relieve symptoms if riboflavin deficiency is the cause. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Vitamin B2 is found in bound form which further reduces its availability. Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation. Riboflavin, also known as vitamin B2, is a vitamin found in food and used as a dietary supplement. Riboflavin status and its association with serum hs-CRP levels among clinical nurses with depression. Humans cannot make riboflavin, so they must get it from foods in their diet. B Vitamin Deficiency: Symptoms and Causes of Low Vitamin B Levels When it comes to vitamins needed for both a sound body and mind, the B vitamins aren’t something you want to ignore. 3. Riboflavin is a key vitamin for your health and has an impact on nearly every system in the body. Biochim Biophys Acta. Some countries require its addition to grains. 0. PreserveArticles.com is a free service that lets you to preserve your original articles for eternity. Secondary riboflavin deficiency – chronic diarrhea – problems with absorption of riboflavin seen with conditions like celiac sprue disease, cancers, and alcoholism It can affect the skin by causing skin crack, itching, and dermatitis around the mouth. 2 2. We postulate that haploinsufficiency of this riboflavin transporter causes mild riboflavin deficiency, and when coupled with nutritional riboflavin deficiency in pregnancy [ncbi.nlm.nih.gov] Maternal riboflavin deficiency , resulting in transient neonatal-onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B. HHS J Am Coll Nutr. A dietary deficiency disease called ariboflavinosis emerges from a long, continued, drastic dietary shortage of riboflavin. Alcoholics are at increased risk of vitamin B2 (riboflavin) deficiency due to decreased intake, decreased absorption, and impaired utilization of riboflavin. This is the first report of a genetic defect in riboflavin transport in humans. USA.gov. It can affect the skin by causing skin crack, itching, and dermatitis around the mouth. Riboflavin deficiency causes various nonspecific skin and mucosal lesions, including maceration of mucosa at the angles of the mouth (angular stomatitis) and surfaces of the lips (cheilosis). People have painful cracks in the corners of the mouth and on the lips, scaly patches on the head, and a magenta mouth and tongue. N/A. Late-Onset Riboflavin Transporter Deficiency: A Treatable Mimic of Motor Neuropathy Etiologies Journal of Neurology, Neurosurgery, and Psychiatry . This condition may progress to eclampsia and cause severe bleeding and death. -. Coward, K. H., and Morgan, B.C. Riboflavin deficiency usually occurs with other B vitamin deficiencies. Its manifestations are glossitis, angular stomatitis, cheilosis, anemia, and peripheral neuropathy.… Riboflavin Deficiency (Riboflavin Deficiency Disease): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. It also causes cheilosis (crack of the lip), angular stomatitis, redness of the tongue, and scrotal dermatitis . Riboflavin deficiency causes various nonspecific skin and mucosal lesions, including maceration of mucosa at the angles of the mouth (angular stomatitis) and surfaces of the lips (cheilosis). Riboflavin has a yellow-green fluorescent pigment, which causes urine to turn yellow, indicating the body is absorbing riboflavin. 2019 Jul;42(4):608-619. Increased elimination of urine) in such circumstances riboflavin is lost increasingly. This site needs JavaScript to work properly. N/A. Those who are more likely to develop riboflavin deficiency include: newborns who receive light therapy for jaundice; people with alcoholism; people with anorexia nervosa (self starvation) Nutrition Riboflavin deficiency. In addition to boosting energy, riboflavin functions as an antioxidant for the proper function of the immune system, healthy skin, and hair. Some of the symptoms of ariboflavinosis or riboflavin deficiency are: Sore lips/throat, swelling and redness of the throat and mouth, cracking of the lips. The major clinical features often relate to cardiac impairment. -, Finsterer J. 2019 Jul;42(4):598-607. Vitamin B2: Riboflavin Deficiency and Severe Fatigue. Riboflavin deficiency can cause ariboflavinosis, which may result in cheilosis (cracks in the lips), high sensitivity to sunlight, angular cheilitis, glossitis (inflammation of the tongue), seborrheic dermatitis or pseudo-syphilis (particularly affecting the scrotum or labia majora and the mouth), pharyngitis (sore throat), hyperemia, and edema of the pharyngeal and oral mucosa. Riboflavin is continuously excreted through the urine, thus increasing the risk of a deficiency when dietary intake is insufficient. Hustad S, McKinley MC, McNulty H, Schneede J, Strain JJ, Scott JM, Ueland PM. Riboflavin transporter deficiency neuronopathy is a disorder that affects nerve cells (neurons). Pasteurisation, evaporation and drying of milk causes 10 to 20 per cent loss of riboflavin. Signs and symptoms of deficiency include: Share on Pinterest A lack of vitamin B2 can lead to mouth ulcers and other complaints. We postulate that haploinsufficiency of this riboflavin transporter causes mild riboflavin deficiency, and when coupled with nutritional riboflavin deficiency in pregnancy, resulted in the transient riboflavin-responsive disease seen in her newborn infant. Nutrition Riboflavin deficiency. It is required by the body for cellular respiration. One of them is a lack of biotin. Riboflavin deficiency: Related Medical Conditions. When there is too little riboflavin in the food, it causes what people call a primary riboflavin deficiency. Because riboflavin assists many enzymes with various daily functions throughout the body, a deficiency can lead to health problems. 4. Animal studies show that the brain and heart disorders and some cancers can develop from long-term riboflavin deficiency. riboflavin deficiency that can affect our body’s metabolism . Riboflavin is present in foods in Free State, in combination with phos­phate or with protein and phosphate. Riboflavin deficiency: Related Medical Conditions. FMN phosphatase and FAD pyrophosphatase in rat intestinal brush borders: role in intestinal absorption of dietary riboflavin. Vitamin B2 – aka riboflavin – is crucial for maintaining adequate energy levels. Hyperemia and edema around the throat, liver degeneration, and hair loss can also occur along with reproductive issues. 2017 May 5;6(5):52. doi: 10.3390/jcm6050052. Copyright © 2020, StatPearls Publishing LLC. To our knowledge, this is the first report to indicate that Rfvt3 contributes to placental riboflavin transport, and that disruption of Slc52a3 gene caused neonatal mortality with hyperlipidemia and hypoglycemia owing to riboflavin deficiency. Riboflavin also helps convert tryptophan to niacin, which activates vitamin B6. An update on diagnosis and therapy of metabolic myopathies. Primary riboflavin deficiency: – inadequate intake of fortified milk, cereals, and other animal products may cause primary riboflavin deficiency. Nichols EK, Talley LE, Birungi N, et al. Cataract and photosensitivity Not getting enough riboflavin or vitamin B2 can cause dermatitis or skin lesion, sores, and itchiness. Riboflavin deficiency is also known as ariboflavinosis. 5. Vitamin B2 (Riboflavin) deficiency symptoms include anemia (interfere iron absorption), blurred vision, itching in eyes, watery eyes, eye fatigue, eye’s increased sensitivity toward light, cataract, dermatitis, migraine, night blindness, cracked corners of the mouth, swollen tongue, throat soreness and weakness. E. 1941. It unites with enzymes to help cells used oxygen. Riboflavin transporter deficiency may be caused by mutations in the SLC52A2 or SLC52A3 genes. Content Guidelines Such as rapid growth pregnancy and lactation signs of riboflavin deficiency may appear. Additionally, anorexic individuals rarely consume adequate riboflavin, and lactose intolerant individuals may not consume milk or other dairy products which are good sources of riboflavin. In addition to inadequate intake, causes of riboflavin deficiency can include endocrine abnormalities (such as thyroid hormone insufficiency) and some diseases . Such as vomiting and nausea interfere with food intake. riboflavin deficiency A condition caused by a relative lack of riboflavin in the diet; riboflavin deficiency is rare, given its wide distribution in foods, and is almost invariably accompanied by deficiencies of other water-soluble vitamins. NLM NCI CPTC Antibody Characterization Program, Lykstad J, Sharma S. StatPearls [Internet] StatPearls Publishing; Treasure Island (FL): 2020. Riboflavin deficiency, also called ariboflavinosis, rarely occurs alone. Before publishing your Article on this site, please read the following pages: 1. Riboflavin is an important co-enzyme in energy metabolism. People who are riboflavin deficient usually also have deficiencies of other B vitamins. A variety of factors may cause brittle hair and nails. 2011 Oct. 30(5):340-7. . Barile M, Giancaspero TA, Brizio C, Panebianco C, Indiveri C, Galluccio M, Vergani L, Eberini I, Gianazza E. Curr Pharm Des. Just Get Enough Riboflavin In Your Diet. Some people who have something wrong with their guts get what people call a secondary riboflavin deficiency: even if there is plenty of riboflavin in the food, the sick gut cannot get it out of the food and pass it on to the blood. Usually, when someone has a riboflavin deficiency, levels of other B-vitamins in the body are also low. 2. Riboflavin (vitamin B2) deficiency is caused by inadequate dietary intake, malabsorption, and impaired metabolism. It may also cause diarrhea and nausea, blurred vision, and anemia. Dietary insufficiency can cause angular cheilitis (cracks at the corners of the mouth), anemia, burning mouth, sore throat, and cataracts. Biosynthesis of flavin cofactors in man: implications in health and disease. Riboflavin deficiency can also play a role in mitochondrial dysfunction in the development of cardiovascular problems. Riboflavin is lost in the process of heating e.g. Our mission is to liberate knowledge. J Inherit Metab Dis. Riboflavin transporter deficiency is a progressive neurodegenerative disease characterized by paralysis of the cranial nerves, sensorineural deafness, and signs of damage to other nerves.Symptoms may begin from infancy to early adulthood and worsen over time. Animal studies show that the brain and heart disorders and some cancers can develop from long-term riboflavin deficiency. Riboflavin deficiency can lead to a whole host of health problems, from fatigue to cataracts. 0. Riboflavin is necessary for normal development, lactation, physical performance, and reproduction. Review Topic. Symptoms and signs include sore throat, lesions of the lips and mucosa of the mouth, glossitis, conjunctivitis, seborrheic dermatitis, and normochromic-normocytic anemia. Deficiency disease of riboflavin Vitamin b2 deficiency diseases or Riboflavin deficiency include oral and facial lesions, sore throat, redness and swelling of mouth lining. Its deficiency causes several ill effects like palpitations, tinnitus, paranesthesia, depressions, dementia, glossitis. Riboflavin transporter deficiency is caused by a variation in one of three genes – SLC52A1 gene (causing riboflavin transporter deficiency type 1), the SLC52A2 gene (riboflavin transporter deficiency type 2), and the SLC52A3 gene (riboflavin transporter deficiency type 3). Below is the list of complications and problems that may arise if Riboflavin deficiency is left untreated: anemia; cataracts; problems in the metabolism of nutrients; reduce the level of flavin coenzymes Riboflavin Responsive Mitochondrial Dysfunction in Neurodegenerative Diseases. Maternal Riboflavin Deficiency, Resulting in Transient Neonatal-Onset Glutaric Aciduria Type 2, Is Caused by a Microdeletion in the Riboflavin Transporter Gene GPR172B Hum Mutat . Riboflavin Deficiency Definition Riboflavin deficiency occurs when the chronic failure to eat sufficient amounts of foods that contain riboflavin produces lesions of the skin, lesions of smooth surfaces in the digestive tract, or nervous disorders. doi: 10.1002/humu.21399. Diagnosis is usually clinical. Questions. Defects in the functioning of the nervous system also…